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Therapy

In recent years numerous life-saving treatment options have been developed for the therapy of breast cancer. Today there is a wide selection of treatments available to fight each individual breast cancer type. For a personalized treatment recommendation different approaches are selected and combined based on a sound diagnosis.

Clinical parameters guide the oncologist in assessing the suitable intervention e.g.:

  • Surgery
  • Sentinel lymph node biopsy
  • Radiation therapy

In order to optimize the outcome the treatment regimen is typically complemented by a systemic therapy like:

  • Chemotherapy
  • Anti-hormone therapy
  • Targeted therapy

Therapy Pathways

BCS (Breast Conserving Surgery)
based on http://onkopedia-guidelines.info

Based on the identified molecular subtype the 13th St Gallen International Breast Cancer Conference (2013) Expert Panel has established clear recommendations for the choice of most effective systemic treatments.

Subtype Systemic Therapy Benefits of MammaTyper®
Luminal A-like Endocrine therapy Based on accurate measurement MammaTyper® supports differentiation of low risk
Luminal A-like from high risk Luminal B-like by precise and reproducible MKI67 determination
Luminal B-like (HER2 negative) Endocrine therapy
+
Cytotoxics
Accurate determination of hormone receptor > endocrine responder or non –responder
Precise differentiation of low risk Luminal A-like from high risk Luminal B-like by accurate and reproducible MKI67 determination by MammaTyper®
Luminal B-like (HER2 positive) Endocrine therapy
+
Cytotoxics
+
Anti-HER2
Accurate determination of hormone receptor expression by MammaTyper® > endocrine responder or non –responder

Accurate determination of ERBB2 expression by MammaTyper®
HER2 positive (non-luminal) Anti-HER2 Accurate determination of ERBB2 expression by MammaTyper®
Triple negative (ductal) Cytotoxics Accurate determination of ERBB2, ESR1, PGR expression negativity by MammaTyper®